Drug interactions
Oxaprozin + Tolazamide
Severity: Moderate
Oxaprozin and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaprozin may enhance the glucose-lowering effect of tolazamide, raising the risk of hypoglycemia. The effect is most relevant in elderly patients and those with renal impairment.
What this interaction means in plain words
Oxaprozin and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaprozin belongs to Musculoskeletal; Tolazamide belongs to Endocrine.
Why it happens
Highly protein-bound NSAIDs may displace sulfonylureas from albumin and prostaglandin inhibition may alter insulin secretion, though the mechanism is not firmly established.
What to do
Monitor blood glucose more frequently when starting or stopping oxaprozin and reduce the tolazamide dose if hypoglycemia occurs. Counsel the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Oxaprozin with Tolazamide?
MediHelp rates the interaction as moderate. Oxaprozin and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaprozin may enhance the glucose-lowering effect of tolazamide, raising the risk of hypoglycemia. The effect is most relevant in elderly patients and those with renal impairment.
How serious is the interaction between Oxaprozin and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or stopping oxaprozin and reduce the tolazamide dose if hypoglycemia occurs. Counsel the patient on hypoglycemia symptoms.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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