Drug interactions
Oxaprozin + Tolbutamide
Severity: Moderate
Oxaprozin and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaprozin may potentiate the hypoglycemic action of tolbutamide. Episodes of low blood glucose may occur, especially in older or renally impaired patients.
What this interaction means in plain words
Oxaprozin and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaprozin belongs to Musculoskeletal; Tolbutamide belongs to Endocrine.
Why it happens
Possible protein-binding displacement of the sulfonylurea and prostaglandin-related effects on insulin secretion; the mechanism is not firmly established.
What to do
Check blood glucose closely when oxaprozin is started or stopped and lower the tolbutamide dose if hypoglycemia develops. Educate the patient about hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Oxaprozin with Tolbutamide?
MediHelp rates the interaction as moderate. Oxaprozin and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaprozin may potentiate the hypoglycemic action of tolbutamide. Episodes of low blood glucose may occur, especially in older or renally impaired patients.
How serious is the interaction between Oxaprozin and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose closely when oxaprozin is started or stopped and lower the tolbutamide dose if hypoglycemia develops. Educate the patient about hypoglycemia symptoms.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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