Drug interactions
Oxaprozin + Vancomycin
Severity: Minor
Oxaprozin and Vancomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal perfusion and glomerular filtration, which may raise vancomycin concentrations. Reports are mainly in neonates and preterm infants, and the effect may add to vancomycin nephrotoxicity risk.
What this interaction means in plain words
Oxaprozin and Vancomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oxaprozin belongs to Musculoskeletal; Vancomycin belongs to Anti Bacterial.
Why it happens
NSAID-mediated inhibition of renal prostaglandins reduces renal blood flow and vancomycin clearance.
What to do
Monitor serum creatinine and vancomycin trough or AUC levels, especially in neonates or patients with renal impairment, and adjust the vancomycin dose accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Oxaprozin with Vancomycin?
MediHelp rates the interaction as minor. Oxaprozin and Vancomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs can reduce renal perfusion and glomerular filtration, which may raise vancomycin concentrations. Reports are mainly in neonates and preterm infants, and the effect may add to vancomycin nephrotoxicity risk.
How serious is the interaction between Oxaprozin and Vancomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and vancomycin trough or AUC levels, especially in neonates or patients with renal impairment, and adjust the vancomycin dose accordingly.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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