Drug interactions
Oxaprozin + Voclosporin
Severity: Major
Oxaprozin and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor that can reduce glomerular filtration, and NSAIDs add renal vasoconstriction through prostaglandin inhibition. Together they increase the risk of acute kidney injury and hyperkalemia.
What this interaction means in plain words
Oxaprozin and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxaprozin belongs to Musculoskeletal; Voclosporin belongs to Miscellaneous.
Why it happens
Additive afferent arteriolar constriction from calcineurin inhibition and NSAID inhibition of vasodilatory prostaglandins.
What to do
Avoid NSAIDs where possible in patients on voclosporin, and monitor eGFR, creatinine and potassium closely if they are needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Oxaprozin with Voclosporin?
MediHelp rates the interaction as major. Oxaprozin and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voclosporin is a calcineurin inhibitor that can reduce glomerular filtration, and NSAIDs add renal vasoconstriction through prostaglandin inhibition. Together they increase the risk of acute kidney injury and hyperkalemia.
How serious is the interaction between Oxaprozin and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs where possible in patients on voclosporin, and monitor eGFR, creatinine and potassium closely if they are needed.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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