Drug interactions
Oxaprozin + Warfarin
Severity: Major
Oxaprozin and Warfarin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs increase bleeding risk with warfarin through platelet inhibition and gastric mucosal injury, and may modestly displace warfarin from protein binding. Serious gastrointestinal bleeding is the main concern.
What this interaction means in plain words
Oxaprozin and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxaprozin belongs to Musculoskeletal; Warfarin belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect from NSAID platelet inhibition and mucosal damage, with possible protein-binding displacement of warfarin.
What to do
Avoid the combination where possible and use acetaminophen for analgesia. If necessary, monitor INR closely, consider gastroprotection and watch for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Oxaprozin with Warfarin?
MediHelp rates the interaction as major. Oxaprozin and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs increase bleeding risk with warfarin through platelet inhibition and gastric mucosal injury, and may modestly displace warfarin from protein binding. Serious gastrointestinal bleeding is the main concern.
How serious is the interaction between Oxaprozin and Warfarin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use acetaminophen for analgesia. If necessary, monitor INR closely, consider gastroprotection and watch for bleeding.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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