Drug interactions
Oxcarbazepine + Rivaroxaban
Severity: Moderate
Oxcarbazepine and Rivaroxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine is a weak inducer of CYP3A4 and may lower rivaroxaban concentrations modestly. Reduced anticoagulant exposure could lead to loss of protection against stroke or thromboembolism.
What this interaction means in plain words
Oxcarbazepine and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxcarbazepine belongs to Central Nervous System; Rivaroxaban belongs to Cardiovascular.
Why it happens
Induction of CYP3A4 (and possibly P-glycoprotein) increases rivaroxaban metabolism.
What to do
Monitor for signs of thromboembolism or reduced efficacy. Consider an alternative anticoagulant or antiepileptic if the clinical picture suggests underexposure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Oxcarbazepine with Rivaroxaban?
MediHelp rates the interaction as moderate. Oxcarbazepine and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine is a weak inducer of CYP3A4 and may lower rivaroxaban concentrations modestly. Reduced anticoagulant exposure could lead to loss of protection against stroke or thromboembolism.
How serious is the interaction between Oxcarbazepine and Rivaroxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of thromboembolism or reduced efficacy. Consider an alternative anticoagulant or antiepileptic if the clinical picture suggests underexposure.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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