Drug interactions
Oxcarbazepine + Vemurafenib
Severity: Moderate
Oxcarbazepine and Vemurafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib is a CYP3A4 substrate, and inducers can reduce its exposure and efficacy in melanoma. Labeling advises avoiding strong inducers; oxcarbazepine's weaker induction may still matter.
What this interaction means in plain words
Oxcarbazepine and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxcarbazepine belongs to Central Nervous System; Vemurafenib belongs to Oncology.
Why it happens
Oxcarbazepine induces CYP3A4, increasing vemurafenib clearance.
What to do
Choose a non-inducing anticonvulsant where possible; otherwise monitor tumor response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Vemurafenib
Frequently asked questions
Can I take Oxcarbazepine with Vemurafenib?
MediHelp rates the interaction as moderate. Oxcarbazepine and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vemurafenib is a CYP3A4 substrate, and inducers can reduce its exposure and efficacy in melanoma. Labeling advises avoiding strong inducers; oxcarbazepine's weaker induction may still matter.
How serious is the interaction between Oxcarbazepine and Vemurafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose a non-inducing anticonvulsant where possible; otherwise monitor tumor response.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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