Drug interactions
Oxcarbazepine + Voriconazole
Severity: Moderate
Oxcarbazepine and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine can induce metabolism of voriconazole and lower its plasma concentrations, which risks therapeutic failure of antifungal treatment. The induction effect is weaker than that of carbamazepine but is still relevant.
What this interaction means in plain words
Oxcarbazepine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxcarbazepine belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Induction of CYP3A4 and possibly other enzymes by oxcarbazepine increases voriconazole clearance.
What to do
Monitor voriconazole trough concentrations and clinical response, and increase the dose if levels are subtherapeutic. Consider an alternative anticonvulsant if control of the infection is at risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Oxcarbazepine with Voriconazole?
MediHelp rates the interaction as moderate. Oxcarbazepine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine can induce metabolism of voriconazole and lower its plasma concentrations, which risks therapeutic failure of antifungal treatment. The induction effect is weaker than that of carbamazepine but is still relevant.
How serious is the interaction between Oxcarbazepine and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor voriconazole trough concentrations and clinical response, and increase the dose if levels are subtherapeutic. Consider an alternative anticonvulsant if control of the infection is at risk.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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