Drug interactions
Oxybutynin + Perphenazine
Severity: Moderate
Oxybutynin and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine has anticholinergic properties, so combining it with oxybutynin can increase dry mouth, constipation, urinary retention, blurred vision and confusion. Risk is higher in older or cognitively impaired patients.
What this interaction means in plain words
Oxybutynin and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxybutynin belongs to Genitourinary; Perphenazine belongs to Central Nervous System.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor for anticholinergic adverse effects and bowel and bladder function. Consider a non-anticholinergic bladder therapy if effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxybutynin
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Oxybutynin with Perphenazine?
MediHelp rates the interaction as moderate. Oxybutynin and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine has anticholinergic properties, so combining it with oxybutynin can increase dry mouth, constipation, urinary retention, blurred vision and confusion. Risk is higher in older or cognitively impaired patients.
How serious is the interaction between Oxybutynin and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and bowel and bladder function. Consider a non-anticholinergic bladder therapy if effects develop.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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