Drug interactions
Oxybutynin + Ribociclib
Severity: Moderate
Oxybutynin and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor and may raise oxybutynin concentrations, increasing anticholinergic adverse effects. Ribociclib also prolongs the QT interval, which matters if anticholinergic tachycardia occurs.
What this interaction means in plain words
Oxybutynin and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxybutynin belongs to Genitourinary; Ribociclib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated oxybutynin metabolism by ribociclib.
What to do
Monitor for anticholinergic effects and consider reducing the oxybutynin dose. Continue ECG monitoring as required for ribociclib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxybutynin
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Oxybutynin with Ribociclib?
MediHelp rates the interaction as moderate. Oxybutynin and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate CYP3A4 inhibitor and may raise oxybutynin concentrations, increasing anticholinergic adverse effects. Ribociclib also prolongs the QT interval, which matters if anticholinergic tachycardia occurs.
How serious is the interaction between Oxybutynin and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and consider reducing the oxybutynin dose. Continue ECG monitoring as required for ribociclib.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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