Drug interactions
Oxybutynin + Solifenacin
Severity: Moderate
Oxybutynin and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antimuscarinic bladder agents, so combining them duplicates therapy and increases dry mouth, constipation, urinary retention, blurred vision and cognitive effects without clear added benefit.
What this interaction means in plain words
Oxybutynin and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxybutynin belongs to Genitourinary; Solifenacin belongs to Genitourinary.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid concurrent use of two antimuscarinics; optimize one agent or switch class instead.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxybutynin
Other interactions of Solifenacin
Frequently asked questions
Can I take Oxybutynin with Solifenacin?
MediHelp rates the interaction as moderate. Oxybutynin and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are antimuscarinic bladder agents, so combining them duplicates therapy and increases dry mouth, constipation, urinary retention, blurred vision and cognitive effects without clear added benefit.
How serious is the interaction between Oxybutynin and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two antimuscarinics; optimize one agent or switch class instead.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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