Drug interactions
Oxybutynin transdermal + Trazodone
Severity: Minor
Oxybutynin transdermal and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Transdermal oxybutynin is an antimuscarinic with lower systemic levels than the oral form, and trazodone has only weak anticholinergic effects. Additive dry mouth, constipation or urinary retention is possible but usually mild.
What this interaction means in plain words
Oxybutynin transdermal and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive antimuscarinic effects, with trazodone contributing weakly.
What to do
Monitor for anticholinergic symptoms and cognitive effects, especially in older patients. Reduce the oxybutynin dose or switch if these appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Oxybutynin transdermal with Trazodone?
MediHelp rates the interaction as minor. Oxybutynin transdermal and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Transdermal oxybutynin is an antimuscarinic with lower systemic levels than the oral form, and trazodone has only weak anticholinergic effects. Additive dry mouth, constipation or urinary retention is possible but usually mild.
How serious is the interaction between Oxybutynin transdermal and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms and cognitive effects, especially in older patients. Reduce the oxybutynin dose or switch if these appear.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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