Drug interactions
Oxycodone + Pimozide
Severity: Moderate
Oxycodone and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combined use can cause excess drowsiness, impaired psychomotor performance and respiratory depression. Pimozide is also a CYP2D6 and CYP3A4 substrate with QT-prolonging potential, which adds to the need for caution in vulnerable patients.
What this interaction means in plain words
Oxycodone and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxycodone belongs to Musculoskeletal; Pimozide belongs to Central Nervous System.
Why it happens
Additive central nervous system depression from opioid and antipsychotic effects.
What to do
Start oxycodone at the lowest effective dose and monitor sedation and respiratory rate. Counsel the patient about driving and alcohol, and check the ECG if other QT-prolonging risks exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Oxycodone with Pimozide?
MediHelp rates the interaction as moderate. Oxycodone and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combined use can cause excess drowsiness, impaired psychomotor performance and respiratory depression. Pimozide is also a CYP2D6 and CYP3A4 substrate with QT-prolonging potential, which adds to the need for caution in vulnerable patients.
How serious is the interaction between Oxycodone and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start oxycodone at the lowest effective dose and monitor sedation and respiratory rate. Counsel the patient about driving and alcohol, and check the ECG if other QT-prolonging risks exist.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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