Drug interactions
Oxycodone + Protriptyline
Severity: Moderate
Oxycodone and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an opioid with a tricyclic antidepressant can add to sedation, psychomotor impairment and respiratory depression. Protriptyline's anticholinergic effects may also worsen constipation and urinary retention caused by oxycodone.
What this interaction means in plain words
Oxycodone and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant and anticholinergic effects; tricyclics may also have serotonergic activity.
What to do
Start with the lowest effective oxycodone dose and monitor for excess sedation, respiratory depression and anticholinergic effects. Counsel patients about driving and alcohol avoidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Oxycodone with Protriptyline?
MediHelp rates the interaction as moderate. Oxycodone and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an opioid with a tricyclic antidepressant can add to sedation, psychomotor impairment and respiratory depression. Protriptyline's anticholinergic effects may also worsen constipation and urinary retention caused by oxycodone.
How serious is the interaction between Oxycodone and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective oxycodone dose and monitor for excess sedation, respiratory depression and anticholinergic effects. Counsel patients about driving and alcohol avoidance.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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