Drug interactions
Oxycodone + Quinacrine
Severity: Minor
Oxycodone and Quinacrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinacrine may inhibit CYP2D6, reducing conversion of oxycodone to oxymorphone. Oxycodone's own activity is mainly from the parent drug, so the clinical effect is uncertain and probably small.
What this interaction means in plain words
Oxycodone and Quinacrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP2D6 inhibition by quinacrine altering oxycodone metabolism.
What to do
No routine dose change; monitor analgesic response and adverse effects when starting or stopping quinacrine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Oxycodone with Quinacrine?
MediHelp rates the interaction as minor. Oxycodone and Quinacrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinacrine may inhibit CYP2D6, reducing conversion of oxycodone to oxymorphone. Oxycodone's own activity is mainly from the parent drug, so the clinical effect is uncertain and probably small.
How serious is the interaction between Oxycodone and Quinacrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor analgesic response and adverse effects when starting or stopping quinacrine.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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