Drug interactions
Oxycodone + Remimazolam
Severity: Major
Oxycodone and Remimazolam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Remimazolam is a benzodiazepine sedative, and combining it with an opioid increases the risk of deep sedation and respiratory depression. Hypoxia, apnea, coma and death can occur if doses are not reduced.
What this interaction means in plain words
Oxycodone and Remimazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxycodone belongs to Musculoskeletal; Remimazolam belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression from GABA-A potentiation plus mu-opioid agonism.
What to do
Titrate remimazolam carefully, usually at reduced doses, and monitor continuous pulse oximetry and vital signs through sedation and recovery. Ensure personnel and equipment for airway support are available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Remimazolam
Frequently asked questions
Can I take Oxycodone with Remimazolam?
MediHelp rates the interaction as major. Oxycodone and Remimazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Remimazolam is a benzodiazepine sedative, and combining it with an opioid increases the risk of deep sedation and respiratory depression. Hypoxia, apnea, coma and death can occur if doses are not reduced.
How serious is the interaction between Oxycodone and Remimazolam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remimazolam carefully, usually at reduced doses, and monitor continuous pulse oximetry and vital signs through sedation and recovery. Ensure personnel and equipment for airway support are available.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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