Drug interactions
Oxycodone + Selegiline transdermal
Severity: Major
Oxycodone and Selegiline transdermal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is an MAO inhibitor, and opioid use with MAOIs has been associated with serious reactions such as hypotension, hyperthermia, and CNS depression. Labeling for oxycodone advises against use with MAOIs.
What this interaction means in plain words
Oxycodone and Selegiline transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibition may potentiate opioid CNS effects and serotonergic or autonomic reactions; the exact mechanism is not fully established.
What to do
Avoid combining where possible; oxycodone labeling advises against use within 14 days of MAOI therapy. If unavoidable, use low doses and monitor for serotonin toxicity, blood pressure changes, and sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Oxycodone with Selegiline transdermal?
MediHelp rates the interaction as major. Oxycodone and Selegiline transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Selegiline is an MAO inhibitor, and opioid use with MAOIs has been associated with serious reactions such as hypotension, hyperthermia, and CNS depression. Labeling for oxycodone advises against use with MAOIs.
How serious is the interaction between Oxycodone and Selegiline transdermal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; oxycodone labeling advises against use within 14 days of MAOI therapy. If unavoidable, use low doses and monitor for serotonin toxicity, blood pressure changes, and sedation.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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