Drug interactions
Oxycodone + Thiothixene
Severity: Moderate
Oxycodone and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antipsychotics such as thiothixene can add to opioid sedation, hypotension and respiratory depression. Impaired alertness and psychomotor performance may be pronounced at the start of therapy.
What this interaction means in plain words
Oxycodone and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through dopaminergic, histaminergic and adrenergic blockade combined with opioid effects.
What to do
Use reduced initial doses of either drug and monitor for sedation, hypotension and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Oxycodone with Thiothixene?
MediHelp rates the interaction as moderate. Oxycodone and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antipsychotics such as thiothixene can add to opioid sedation, hypotension and respiratory depression. Impaired alertness and psychomotor performance may be pronounced at the start of therapy.
How serious is the interaction between Oxycodone and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced initial doses of either drug and monitor for sedation, hypotension and respiratory depression.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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