Drug interactions
Oxycodone + Triprolidine
Severity: Moderate
Oxycodone and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a sedating antihistamine with an opioid increases drowsiness and can add to respiratory depression. The risk is greatest in older, frail or respiratory-compromised patients and at higher opioid doses.
What this interaction means in plain words
Oxycodone and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxycodone belongs to Musculoskeletal; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS and respiratory depression from antihistaminic sedation and opioid receptor agonism.
What to do
Monitor sedation and respiratory rate, and use the lowest effective doses. Prefer a non-sedating antihistamine where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Oxycodone with Triprolidine?
MediHelp rates the interaction as moderate. Oxycodone and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a sedating antihistamine with an opioid increases drowsiness and can add to respiratory depression. The risk is greatest in older, frail or respiratory-compromised patients and at higher opioid doses.
How serious is the interaction between Oxycodone and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory rate, and use the lowest effective doses. Prefer a non-sedating antihistamine where possible.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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