Drug interactions
Oxycodone + Yohimbine
Severity: Minor
Oxycodone and Yohimbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist with stimulant effects that might partly counter opioid sedation, but no reliable clinical interaction is established. It could also raise blood pressure and cause anxiety.
What this interaction means in plain words
Oxycodone and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible pharmacodynamic opposition via alpha-2 antagonism; the interaction is not well characterized.
What to do
No specific adjustment is needed; monitor analgesic effect, blood pressure and anxiety symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Oxycodone with Yohimbine?
MediHelp rates the interaction as minor. Oxycodone and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Yohimbine is an alpha-2 antagonist with stimulant effects that might partly counter opioid sedation, but no reliable clinical interaction is established. It could also raise blood pressure and cause anxiety.
How serious is the interaction between Oxycodone and Yohimbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific adjustment is needed; monitor analgesic effect, blood pressure and anxiety symptoms.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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