Drug interactions
Oxycodone + Zotepine
Severity: Moderate
Oxycodone and Zotepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zotepine is a sedating antipsychotic that can add to oxycodone's CNS depressant effects, causing drowsiness, hypotension and respiratory depression. Zotepine also lowers the seizure threshold.
What this interaction means in plain words
Oxycodone and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via histamine, adrenergic and opioid receptor pathways.
What to do
Use lower starting doses and monitor sedation, blood pressure and respiratory function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Oxycodone with Zotepine?
MediHelp rates the interaction as moderate. Oxycodone and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zotepine is a sedating antipsychotic that can add to oxycodone's CNS depressant effects, causing drowsiness, hypotension and respiratory depression. Zotepine also lowers the seizure threshold.
How serious is the interaction between Oxycodone and Zotepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use lower starting doses and monitor sedation, blood pressure and respiratory function.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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