Drug interactions
Oxymorphone + Prasugrel
Severity: Moderate
Oxymorphone and Prasugrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids delay gastric emptying and can reduce and delay the absorption of oral prasugrel's active metabolite. This may lower early antiplatelet effect, which matters in acute coronary syndromes and PCI.
What this interaction means in plain words
Oxymorphone and Prasugrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxymorphone belongs to Musculoskeletal; Prasugrel belongs to Cardiovascular.
Why it happens
Opioid-induced slowing of gastric emptying reduces oral absorption of prasugrel.
What to do
In acute coronary syndrome, consider a parenteral antiplatelet agent if opioids are needed. Use the lowest effective opioid dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Prasugrel
Frequently asked questions
Can I take Oxymorphone with Prasugrel?
MediHelp rates the interaction as moderate. Oxymorphone and Prasugrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids delay gastric emptying and can reduce and delay the absorption of oral prasugrel's active metabolite. This may lower early antiplatelet effect, which matters in acute coronary syndromes and PCI.
How serious is the interaction between Oxymorphone and Prasugrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In acute coronary syndrome, consider a parenteral antiplatelet agent if opioids are needed. Use the lowest effective opioid dose.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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