Drug interactions
Oxymorphone + Quetiapine
Severity: Moderate
Oxymorphone and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine is markedly sedating and can cause orthostatic hypotension, and with oxymorphone may enhance drowsiness, respiratory depression and falls risk. Elderly and opioid-naive patients are most vulnerable.
What this interaction means in plain words
Oxymorphone and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxymorphone belongs to Musculoskeletal; Quetiapine belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotension via histamine H1 and alpha-1 blockade plus opioid effects.
What to do
Start with reduced doses and titrate cautiously while monitoring sedation, respiratory rate and blood pressure. Counsel on fall prevention and avoiding alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Oxymorphone with Quetiapine?
MediHelp rates the interaction as moderate. Oxymorphone and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine is markedly sedating and can cause orthostatic hypotension, and with oxymorphone may enhance drowsiness, respiratory depression and falls risk. Elderly and opioid-naive patients are most vulnerable.
How serious is the interaction between Oxymorphone and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with reduced doses and titrate cautiously while monitoring sedation, respiratory rate and blood pressure. Counsel on fall prevention and avoiding alcohol.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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