Drug interactions
Oxymorphone + Quinidine
Severity: Minor
Oxymorphone and Quinidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine is a strong CYP2D6 inhibitor, but oxymorphone depends mainly on glucuronidation for clearance, so an important rise in exposure is unlikely. Any effect is probably minor.
What this interaction means in plain words
Oxymorphone and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oxymorphone belongs to Musculoskeletal; Quinidine belongs to Anti Parasitic.
Why it happens
CYP2D6 inhibition has little relevance because oxymorphone is metabolised mainly by UGT2B7.
What to do
No dose adjustment is routinely needed. Monitor for opioid adverse effects after starting quinidine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Oxymorphone and Quinidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Oxymorphone with Quinidine?
MediHelp rates the interaction as minor. Oxymorphone and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinidine is a strong CYP2D6 inhibitor, but oxymorphone depends mainly on glucuronidation for clearance, so an important rise in exposure is unlikely. Any effect is probably minor.
How serious is the interaction between Oxymorphone and Quinidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely needed. Monitor for opioid adverse effects after starting quinidine.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
