Drug interactions
Oxymorphone + Ritonavir
Severity: Minor
Oxymorphone and Ritonavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxymorphone is metabolized mainly by UGT2B7 glucuronidation, with little CYP involvement, so the interaction is mostly theoretical. Ritonavir also affects glucuronidation, so exposure changes are uncertain, and no major effect is expected.
What this interaction means in plain words
Oxymorphone and Ritonavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oxymorphone belongs to Musculoskeletal; Ritonavir belongs to Anti Virals.
Why it happens
Possible modest effect on metabolism, but oxymorphone does not rely on CYP2D6 or CYP3A4.
What to do
No empirical dose change is needed; monitor analgesia and signs of opioid toxicity when starting or stopping ritonavir.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Oxymorphone with Ritonavir?
MediHelp rates the interaction as minor. Oxymorphone and Ritonavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oxymorphone is metabolized mainly by UGT2B7 glucuronidation, with little CYP involvement, so the interaction is mostly theoretical. Ritonavir also affects glucuronidation, so exposure changes are uncertain, and no major effect is expected.
How serious is the interaction between Oxymorphone and Ritonavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor analgesia and signs of opioid toxicity when starting or stopping ritonavir.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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