Drug interactions
Oxymorphone + Sufentanil
Severity: Major
Oxymorphone and Sufentanil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two potent opioids given together produce additive analgesia and respiratory depression. Overdose, apnea and death are possible if doses are not reduced.
What this interaction means in plain words
Oxymorphone and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxymorphone belongs to Musculoskeletal; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive mu-opioid receptor agonism.
What to do
Use only in monitored settings with reduced doses, and ensure respiratory monitoring and access to naloxone.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Oxymorphone with Sufentanil?
MediHelp rates the interaction as major. Oxymorphone and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Two potent opioids given together produce additive analgesia and respiratory depression. Overdose, apnea and death are possible if doses are not reduced.
How serious is the interaction between Oxymorphone and Sufentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only in monitored settings with reduced doses, and ensure respiratory monitoring and access to naloxone.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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