Drug interactions
Oxymorphone + Ticagrelor
Severity: Moderate
Oxymorphone and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids slow gastric emptying and can delay and reduce absorption of oral ticagrelor and its active metabolite. This may reduce early platelet inhibition, which matters most in acute coronary syndrome or around stenting.
What this interaction means in plain words
Oxymorphone and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxymorphone belongs to Musculoskeletal; Ticagrelor belongs to Cardiovascular.
Why it happens
Opioid-induced delayed gastric emptying reduces the rate and extent of ticagrelor absorption.
What to do
In acute coronary syndrome, consider a parenteral antiplatelet agent if an opioid is required. For stable chronic use no specific adjustment is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Oxymorphone with Ticagrelor?
MediHelp rates the interaction as moderate. Oxymorphone and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids slow gastric emptying and can delay and reduce absorption of oral ticagrelor and its active metabolite. This may reduce early platelet inhibition, which matters most in acute coronary syndrome or around stenting.
How serious is the interaction between Oxymorphone and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In acute coronary syndrome, consider a parenteral antiplatelet agent if an opioid is required. For stable chronic use no specific adjustment is needed.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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