Drug interactions
Ozanimod + Phenytoin
Severity: Moderate
Ozanimod and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin may lower exposure to active ozanimod metabolites, potentially reducing efficacy in multiple sclerosis or ulcerative colitis.
What this interaction means in plain words
Ozanimod and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Phenytoin belongs to Central Nervous System.
Why it happens
Phenytoin is an enzyme inducer that may increase metabolic clearance of ozanimod and its active metabolites, including via CYP2C8-related pathways.
What to do
Avoid combination if possible, preferring a non-inducing anticonvulsant. Monitor disease activity if both are needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Phenytoin?
MediHelp rates the interaction as moderate. Ozanimod and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin may lower exposure to active ozanimod metabolites, potentially reducing efficacy in multiple sclerosis or ulcerative colitis.
How serious is the interaction between Ozanimod and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination if possible, preferring a non-inducing anticonvulsant. Monitor disease activity if both are needed.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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