Drug interactions
Ozanimod + Pimozide
Severity: Major
Ozanimod and Pimozide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow the heart rate and delay AV conduction, and pimozide prolongs the QT interval. Bradycardia increases vulnerability to torsades de pointes with QT-prolonging drugs.
What this interaction means in plain words
Ozanimod and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ozanimod belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Additive proarrhythmic effects of S1P-modulator bradycardia and pimozide QT prolongation.
What to do
Avoid starting ozanimod in patients taking pimozide unless benefit outweighs risk, and obtain cardiology advice. Monitor heart rate and ECG when initiating.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Pimozide?
MediHelp rates the interaction as major. Ozanimod and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ozanimod can slow the heart rate and delay AV conduction, and pimozide prolongs the QT interval. Bradycardia increases vulnerability to torsades de pointes with QT-prolonging drugs.
How serious is the interaction between Ozanimod and Pimozide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting ozanimod in patients taking pimozide unless benefit outweighs risk, and obtain cardiology advice. Monitor heart rate and ECG when initiating.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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