Drug interactions
Ozanimod + Remifentanil
Severity: Moderate
Ozanimod and Remifentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolite inhibits MAO-B in vitro, and combining it with agents affecting monoamines may cause hypertensive or serotonergic reactions. Remifentanil is a pure phenylpiperidine opioid with little serotonergic activity, so the actual risk is probably low.
What this interaction means in plain words
Ozanimod and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Remifentanil belongs to Musculoskeletal.
Why it happens
Theoretical MAO-B inhibition by ozanimod metabolite, potentiating sympathomimetic or serotonergic effects.
What to do
Monitor blood pressure and heart rate during remifentanil use and watch for signs of serotonin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Remifentanil?
MediHelp rates the interaction as moderate. Ozanimod and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod's active metabolite inhibits MAO-B in vitro, and combining it with agents affecting monoamines may cause hypertensive or serotonergic reactions. Remifentanil is a pure phenylpiperidine opioid with little serotonergic activity, so the actual risk is probably low.
How serious is the interaction between Ozanimod and Remifentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during remifentanil use and watch for signs of serotonin toxicity.
What other medicines interact with Remifentanil?
MediHelp also lists interactions of Remifentanil with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Remifentanil page.
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