Drug interactions
Paclitaxel + Rifapentine
Severity: Moderate
Paclitaxel and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces CYP2C8 and CYP3A4 and may lower paclitaxel concentrations, potentially reducing efficacy.
What this interaction means in plain words
Paclitaxel and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paclitaxel belongs to Oncology; Rifapentine belongs to Anti Bacterial.
Why it happens
Induction of CYP2C8 and CYP3A4 by rifapentine increases paclitaxel metabolism.
What to do
Avoid the combination if alternatives exist; otherwise monitor treatment response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Paclitaxel with Rifapentine?
MediHelp rates the interaction as moderate. Paclitaxel and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine induces CYP2C8 and CYP3A4 and may lower paclitaxel concentrations, potentially reducing efficacy.
How serious is the interaction between Paclitaxel and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if alternatives exist; otherwise monitor treatment response.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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