Drug interactions
Paclitaxel + Sarecycline
Severity: Minor
Paclitaxel and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline might modestly increase paclitaxel exposure through P-glycoprotein inhibition. Clinical relevance is uncertain given the low systemic exposure of sarecycline.
What this interaction means in plain words
Paclitaxel and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paclitaxel belongs to Oncology; Sarecycline belongs to Anti Bacterial.
Why it happens
Possible weak inhibition of P-glycoprotein efflux of paclitaxel.
What to do
No empirical dose change is needed. Monitor for paclitaxel toxicity such as neutropenia and neuropathy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paclitaxel
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Paclitaxel with Sarecycline?
MediHelp rates the interaction as minor. Paclitaxel and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline might modestly increase paclitaxel exposure through P-glycoprotein inhibition. Clinical relevance is uncertain given the low systemic exposure of sarecycline.
How serious is the interaction between Paclitaxel and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor for paclitaxel toxicity such as neutropenia and neuropathy.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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