Drug interactions
Paclitaxel + Secobarbital
Severity: Moderate
Paclitaxel and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may lower paclitaxel exposure and reduce its antitumor effect. Enzyme-inducing anticonvulsants have been shown to increase paclitaxel clearance.
What this interaction means in plain words
Paclitaxel and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paclitaxel belongs to Oncology; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate induction of CYP2C8 and CYP3A4, the main enzymes metabolizing paclitaxel.
What to do
Prefer a non-inducing sedative where possible. If the combination is needed, monitor tumor response and toxicity closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Paclitaxel and Secobarbital, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Paclitaxel
Frequently asked questions
Can I take Paclitaxel with Secobarbital?
MediHelp rates the interaction as moderate. Paclitaxel and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital may lower paclitaxel exposure and reduce its antitumor effect. Enzyme-inducing anticonvulsants have been shown to increase paclitaxel clearance.
How serious is the interaction between Paclitaxel and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing sedative where possible. If the combination is needed, monitor tumor response and toxicity closely.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
