Drug interactions
Paclitaxel + Voxelotor
Severity: Moderate
Paclitaxel and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and may increase exposure to CYP3A substrates. Paclitaxel has a narrow therapeutic index, so higher levels could increase myelosuppression and neuropathy.
What this interaction means in plain words
Paclitaxel and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paclitaxel belongs to Oncology; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4, reducing paclitaxel metabolism.
What to do
Monitor blood counts and neuropathy, and reduce the paclitaxel dose if toxicity occurs. Consider whether voxelotor can be withheld during chemotherapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Paclitaxel with Voxelotor?
MediHelp rates the interaction as moderate. Paclitaxel and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor inhibits CYP3A4 and may increase exposure to CYP3A substrates. Paclitaxel has a narrow therapeutic index, so higher levels could increase myelosuppression and neuropathy.
How serious is the interaction between Paclitaxel and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy, and reduce the paclitaxel dose if toxicity occurs. Consider whether voxelotor can be withheld during chemotherapy.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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