Drug interactions
Paclitaxel + Zafirlukast
Severity: Minor
Paclitaxel and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel is cleared by CYP2C8 and CYP3A4, and zafirlukast may weakly inhibit CYP3A4. A significant increase in paclitaxel toxicity is theoretical only.
What this interaction means in plain words
Paclitaxel and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paclitaxel belongs to Oncology; Zafirlukast belongs to Respiratory.
Why it happens
Possible weak CYP3A4 inhibition by zafirlukast reducing paclitaxel clearance.
What to do
No empiric dose change is needed. Monitor blood counts and neuropathy as part of routine paclitaxel care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Paclitaxel
Frequently asked questions
Can I take Paclitaxel with Zafirlukast?
MediHelp rates the interaction as minor. Paclitaxel and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paclitaxel is cleared by CYP2C8 and CYP3A4, and zafirlukast may weakly inhibit CYP3A4. A significant increase in paclitaxel toxicity is theoretical only.
How serious is the interaction between Paclitaxel and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Monitor blood counts and neuropathy as part of routine paclitaxel care.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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