Drug interactions
Paclitaxel protein bound + Ranolazine
Severity: Minor
Paclitaxel protein bound and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine inhibits P-glycoprotein and may modestly raise exposure to P-gp substrates. The clinical effect on nab-paclitaxel is not well characterized, but higher exposure could increase myelosuppression and neuropathy.
What this interaction means in plain words
Paclitaxel protein bound and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of P-glycoprotein efflux by ranolazine, which may reduce paclitaxel efflux.
What to do
No routine dose change is needed. Monitor blood counts and signs of peripheral neuropathy as part of standard chemotherapy care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Paclitaxel protein bound with Ranolazine?
MediHelp rates the interaction as minor. Paclitaxel protein bound and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranolazine inhibits P-glycoprotein and may modestly raise exposure to P-gp substrates. The clinical effect on nab-paclitaxel is not well characterized, but higher exposure could increase myelosuppression and neuropathy.
How serious is the interaction between Paclitaxel protein bound and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor blood counts and signs of peripheral neuropathy as part of standard chemotherapy care.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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