Drug interactions
Palbociclib + Pimozide
Severity: Major
Palbociclib and Pimozide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palbociclib is a weak-to-moderate time-dependent CYP3A inhibitor and pimozide is a sensitive, narrow-therapeutic-index CYP3A4 substrate. Higher pimozide exposure raises the risk of QT prolongation and torsades de pointes. Palbociclib itself may also have modest QT effects.
What this interaction means in plain words
Palbociclib and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Palbociclib belongs to Oncology; Pimozide belongs to Central Nervous System.
Why it happens
Palbociclib inhibits CYP3A4, reducing pimozide clearance.
What to do
Avoid the combination if possible; otherwise reduce the pimozide dose and monitor ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Palbociclib
Frequently asked questions
Can I take Palbociclib with Pimozide?
MediHelp rates the interaction as major. Palbociclib and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Palbociclib is a weak-to-moderate time-dependent CYP3A inhibitor and pimozide is a sensitive, narrow-therapeutic-index CYP3A4 substrate. Higher pimozide exposure raises the risk of QT prolongation and torsades de pointes. Palbociclib itself may also have modest QT effects.
How serious is the interaction between Palbociclib and Pimozide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise reduce the pimozide dose and monitor ECG and electrolytes.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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