Drug interactions
Palbociclib + Triazolam
Severity: Moderate
Palbociclib and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palbociclib is a weak CYP3A4 inhibitor and can increase exposure to triazolam, a sensitive CYP3A4 substrate. This may cause excess sedation, confusion and psychomotor impairment.
What this interaction means in plain words
Palbociclib and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Palbociclib inhibits intestinal and hepatic CYP3A4, reducing triazolam clearance.
What to do
Use the lowest effective triazolam dose and monitor for oversedation, or choose a benzodiazepine not metabolized by CYP3A4 such as temazepam.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Palbociclib
Frequently asked questions
Can I take Palbociclib with Triazolam?
MediHelp rates the interaction as moderate. Palbociclib and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palbociclib is a weak CYP3A4 inhibitor and can increase exposure to triazolam, a sensitive CYP3A4 substrate. This may cause excess sedation, confusion and psychomotor impairment.
How serious is the interaction between Palbociclib and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective triazolam dose and monitor for oversedation, or choose a benzodiazepine not metabolized by CYP3A4 such as temazepam.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Palbociclib page.
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