Drug interactions
Palifermin + Ribociclib
Severity: Moderate
Palifermin and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin stimulates epithelial cell growth, and when given close to cytotoxic chemotherapy it has been associated with worse and longer oral mucositis. Ribociclib is an antineoplastic agent, so the same concern is applied, although data specific to ribociclib are lacking.
What this interaction means in plain words
Palifermin and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Palifermin belongs to Miscellaneous; Ribociclib belongs to Oncology.
Why it happens
Palifermin-induced proliferation of mucosal epithelium may sensitize rapidly dividing cells to cytotoxic drugs; not studied specifically with ribociclib.
What to do
Follow palifermin labeling by not giving it within 24 hours before, during, or after cytotoxic therapy, and monitor for mucositis if the timing overlaps.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Palifermin
Frequently asked questions
Can I take Palifermin with Ribociclib?
MediHelp rates the interaction as moderate. Palifermin and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palifermin stimulates epithelial cell growth, and when given close to cytotoxic chemotherapy it has been associated with worse and longer oral mucositis. Ribociclib is an antineoplastic agent, so the same concern is applied, although data specific to ribociclib are lacking.
How serious is the interaction between Palifermin and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow palifermin labeling by not giving it within 24 hours before, during, or after cytotoxic therapy, and monitor for mucositis if the timing overlaps.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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