Drug interactions
Paliperidone + Selegiline
Severity: Moderate
Paliperidone and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is a dopaminergic MAO-B inhibitor and directly opposes the dopamine blockade of paliperidone, which may reduce effectiveness of either drug and worsen parkinsonism or psychosis. Serotonergic toxicity is a theoretical concern.
What this interaction means in plain words
Paliperidone and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paliperidone belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between dopamine agonism and D2 blockade, with possible additive serotonergic effects.
What to do
Monitor motor symptoms, psychiatric status and signs of serotonin toxicity. Adjust doses based on response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Paliperidone with Selegiline?
MediHelp rates the interaction as moderate. Paliperidone and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selegiline is a dopaminergic MAO-B inhibitor and directly opposes the dopamine blockade of paliperidone, which may reduce effectiveness of either drug and worsen parkinsonism or psychosis. Serotonergic toxicity is a theoretical concern.
How serious is the interaction between Paliperidone and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor symptoms, psychiatric status and signs of serotonin toxicity. Adjust doses based on response.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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