Drug interactions
Paliperidone + Sotorasib
Severity: Minor
Paliperidone and Sotorasib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a P-glycoprotein inhibitor and paliperidone is a P-gp substrate, so paliperidone exposure may increase. The expected effect is modest.
What this interaction means in plain words
Paliperidone and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paliperidone belongs to Central Nervous System; Sotorasib belongs to Oncology.
Why it happens
Inhibition of intestinal P-glycoprotein efflux by sotorasib, increasing paliperidone absorption.
What to do
No routine dose change is needed. Monitor for paliperidone adverse effects such as orthostasis, sedation and extrapyramidal symptoms, and reduce the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Paliperidone with Sotorasib?
MediHelp rates the interaction as minor. Paliperidone and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sotorasib is a P-glycoprotein inhibitor and paliperidone is a P-gp substrate, so paliperidone exposure may increase. The expected effect is modest.
How serious is the interaction between Paliperidone and Sotorasib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for paliperidone adverse effects such as orthostasis, sedation and extrapyramidal symptoms, and reduce the dose if they occur.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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