Drug interactions
Paliperidone + Telavancin
Severity: Moderate
Paliperidone and Telavancin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paliperidone is associated with dose-related QTc prolongation and telavancin may add to this. The combination may increase the risk of torsades de pointes, especially in patients with renal impairment, where paliperidone exposure rises.
What this interaction means in plain words
Paliperidone and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paliperidone belongs to Central Nervous System; Telavancin belongs to Anti Bacterial.
Why it happens
Additive QTc prolongation; telavancin nephrotoxicity could also raise paliperidone exposure.
What to do
Monitor ECG and renal function during treatment. Correct electrolytes and adjust paliperidone dose if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Paliperidone with Telavancin?
MediHelp rates the interaction as moderate. Paliperidone and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paliperidone is associated with dose-related QTc prolongation and telavancin may add to this. The combination may increase the risk of torsades de pointes, especially in patients with renal impairment, where paliperidone exposure rises.
How serious is the interaction between Paliperidone and Telavancin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and renal function during treatment. Correct electrolytes and adjust paliperidone dose if renal function declines.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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