Drug interactions
Paliperidone + Tolterodine
Severity: Moderate
Paliperidone and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paliperidone has mild anticholinergic effects, and with tolterodine this can add to dry mouth, constipation and urinary retention. Both drugs may also prolong the QT interval slightly.
What this interaction means in plain words
Paliperidone and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paliperidone belongs to Central Nervous System; Tolterodine belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects and possible additive QT prolongation.
What to do
Monitor for anticholinergic effects and consider an ECG if other QT-prolonging risks are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Paliperidone with Tolterodine?
MediHelp rates the interaction as moderate. Paliperidone and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paliperidone has mild anticholinergic effects, and with tolterodine this can add to dry mouth, constipation and urinary retention. Both drugs may also prolong the QT interval slightly.
How serious is the interaction between Paliperidone and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and consider an ECG if other QT-prolonging risks are present.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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