Drug interactions
Paliperidone + Tolvaptan
Severity: Minor
Paliperidone and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan inhibits P-glycoprotein, which transports paliperidone, so paliperidone exposure may rise modestly. The clinical consequence is likely small but could increase dose-related adverse effects such as sedation, orthostasis and QT prolongation.
What this interaction means in plain words
Paliperidone and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paliperidone belongs to Central Nervous System; Tolvaptan belongs to Endocrine.
Why it happens
Tolvaptan inhibits P-glycoprotein efflux, potentially increasing paliperidone absorption and reducing its clearance.
What to do
No empiric dose change; watch for increased paliperidone adverse effects such as sedation, orthostatic hypotension and extrapyramidal symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Paliperidone with Tolvaptan?
MediHelp rates the interaction as minor. Paliperidone and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolvaptan inhibits P-glycoprotein, which transports paliperidone, so paliperidone exposure may rise modestly. The clinical consequence is likely small but could increase dose-related adverse effects such as sedation, orthostasis and QT prolongation.
How serious is the interaction between Paliperidone and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change; watch for increased paliperidone adverse effects such as sedation, orthostatic hypotension and extrapyramidal symptoms.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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