Drug interactions
Pancuronium + Quinidine
Severity: Moderate
Pancuronium and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine has neuromuscular blocking properties and can potentiate non-depolarizing blockers such as pancuronium, with reports of prolonged or recurrent paralysis. This is relevant perioperatively and in the recovery period.
What this interaction means in plain words
Pancuronium and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pancuronium belongs to Musculoskeletal; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine has intrinsic curare-like effects at the neuromuscular junction that add to the competitive blockade by pancuronium.
What to do
Monitor neuromuscular function with train-of-four and reduce pancuronium doses as needed. Watch for recurrent weakness or respiratory depression after reversal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pancuronium
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Pancuronium with Quinidine?
MediHelp rates the interaction as moderate. Pancuronium and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine has neuromuscular blocking properties and can potentiate non-depolarizing blockers such as pancuronium, with reports of prolonged or recurrent paralysis. This is relevant perioperatively and in the recovery period.
How serious is the interaction between Pancuronium and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four and reduce pancuronium doses as needed. Watch for recurrent weakness or respiratory depression after reversal.
What other medicines interact with Pancuronium?
MediHelp also lists interactions of Pancuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Pancuronium page.
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