Drug interactions
Panobinostat + Salbutamol
Severity: Moderate
Panobinostat and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat can prolong the QT interval and cause arrhythmias, and its labeling advises caution with other QT-prolonging drugs. Salbutamol can add to this risk through hypokalemia and cardiac stimulation.
What this interaction means in plain words
Panobinostat and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Panobinostat belongs to Oncology; Salbutamol belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization, with beta-2 mediated hypokalemia.
What to do
Monitor ECG and keep potassium and magnesium within normal range during panobinostat therapy. Limit salbutamol to what is clinically needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Panobinostat with Salbutamol?
MediHelp rates the interaction as moderate. Panobinostat and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Panobinostat can prolong the QT interval and cause arrhythmias, and its labeling advises caution with other QT-prolonging drugs. Salbutamol can add to this risk through hypokalemia and cardiac stimulation.
How serious is the interaction between Panobinostat and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and keep potassium and magnesium within normal range during panobinostat therapy. Limit salbutamol to what is clinically needed.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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