Drug interactions
Panobinostat + Venlafaxine
Severity: Moderate
Panobinostat and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat inhibits CYP2D6 and may raise venlafaxine levels while reducing formation of its active metabolite O-desmethylvenlafaxine. The net clinical effect is uncertain. Both drugs can also affect the QT interval and panobinostat carries a QT warning.
What this interaction means in plain words
Panobinostat and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Panobinostat belongs to Oncology; Venlafaxine belongs to Central Nervous System.
Why it happens
Panobinostat inhibits CYP2D6, altering venlafaxine metabolism.
What to do
Monitor for venlafaxine adverse effects such as blood pressure rise and consider ECG monitoring given panobinostat's QT risk. Adjust the venlafaxine dose by clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Panobinostat with Venlafaxine?
MediHelp rates the interaction as moderate. Panobinostat and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Panobinostat inhibits CYP2D6 and may raise venlafaxine levels while reducing formation of its active metabolite O-desmethylvenlafaxine. The net clinical effect is uncertain. Both drugs can also affect the QT interval and panobinostat carries a QT warning.
How serious is the interaction between Panobinostat and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for venlafaxine adverse effects such as blood pressure rise and consider ECG monitoring given panobinostat's QT risk. Adjust the venlafaxine dose by clinical response.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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