Drug interactions
Pantoprazole + Voriconazole
Severity: Minor
Pantoprazole and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP2C19 and CYP3A4, which metabolize pantoprazole, so pantoprazole levels may rise. Pantoprazole has a wide safety margin, so the clinical effect is usually limited, though voriconazole levels may also be modestly affected by acid suppression.
What this interaction means in plain words
Pantoprazole and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pantoprazole belongs to Gastrointestinal Tract; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP2C19 and CYP3A4, reducing pantoprazole clearance.
What to do
No routine dose change is needed; consider reducing pantoprazole in patients on long-term high doses or with hepatic impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Frequently asked questions
Can I take Pantoprazole with Voriconazole?
MediHelp rates the interaction as minor. Pantoprazole and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voriconazole inhibits CYP2C19 and CYP3A4, which metabolize pantoprazole, so pantoprazole levels may rise. Pantoprazole has a wide safety margin, so the clinical effect is usually limited, though voriconazole levels may also be modestly affected by acid suppression.
How serious is the interaction between Pantoprazole and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; consider reducing pantoprazole in patients on long-term high doses or with hepatic impairment.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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