Drug interactions
Papaveretum + Risperidone
Severity: Moderate
Papaveretum and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum contains opium alkaloids including morphine, which cause CNS and respiratory depression. Combined with risperidone, sedation, hypotension and psychomotor impairment may be increased.
What this interaction means in plain words
Papaveretum and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects of opioid agonism and antipsychotic receptor blockade.
What to do
Start with the lowest effective opioid dose and monitor sedation, blood pressure and respiratory rate. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Papaveretum with Risperidone?
MediHelp rates the interaction as moderate. Papaveretum and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Papaveretum contains opium alkaloids including morphine, which cause CNS and respiratory depression. Combined with risperidone, sedation, hypotension and psychomotor impairment may be increased.
How serious is the interaction between Papaveretum and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective opioid dose and monitor sedation, blood pressure and respiratory rate. Counsel patients to avoid driving and alcohol.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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