Drug interactions
Papaveretum + Trimipramine
Severity: Major
Papaveretum and Trimipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum contains opium alkaloids including morphine, which add to trimipramine's sedative effects. The combination can cause profound sedation, respiratory depression and hypotension, with greater risk at higher doses.
What this interaction means in plain words
Papaveretum and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid and sedating tricyclic activity.
What to do
Start with reduced opioid doses and monitor sedation and respiratory rate. Avoid alcohol and other CNS depressants.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Papaveretum with Trimipramine?
MediHelp rates the interaction as major. Papaveretum and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Papaveretum contains opium alkaloids including morphine, which add to trimipramine's sedative effects. The combination can cause profound sedation, respiratory depression and hypotension, with greater risk at higher doses.
How serious is the interaction between Papaveretum and Trimipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with reduced opioid doses and monitor sedation and respiratory rate. Avoid alcohol and other CNS depressants.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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